PHARMACEUTICAL COMPOSITION CONTAINING TAMSULOSIN HYDROCHLORIDE WITH EXCELLENT ACID RESISTANCE AND PREPARATION METHOD THEREFOR
The present invention relates to a pharmaceutical composition containing tamsulosin hydrochloride with excellent acid resistance and a preparation method therefor, and to a pharmaceutical composition in which, by coating prepared core beads, which comprise tamsulosin hydrochloride as an active ingredient, with an enteric coating liquid prepared using a certain amount of a plasticizer, adding a buffer base and the like to adjust density, and then mixing and tableting a mixed portion and a lubricant, even after the tableting, the enteric coating is not broken and acid resistance is maintained. Thus, the present invention has good tabletability, excellent content uniformity, excellent acid resistance due to a low dissolution rate of tamsulosin hydrochloride, and no significant decomposition of tamsulosin hydrochloride, and thus, stability can be ensured.
» Number: WO2020130385A1 (A1)
» Publication Date: 25/06/2020
» Applicant: HANMI PHARM IND CO LTD?[KR]
» Inventor: HA EUN HO?[KR]; LEE SEUNG JUN?[KR] (2)