A novel pH-sensitive and magnetic starch-based nanocomposite hydrogel as a controlled drug delivery system for wound healing

pH-sensitive magnetic nanocomposite hydrogel was fabricated by the graft copolymerization of itaconic acid onto starch in the presence of Fe3O4 nanoparticles for Guaifenesin (GFN) delivery and wound healing. The structure of the prepared nanocomposite hydrogels was characterized using FTIR, XRD, SEM, AFM, TEM, DLS, EDX and TGA/DTG techniques. The embedment of Fe3O4 nanoparticles into starch-itaconic acid hydrogel network endowed the material with magnetic property. In addition, GFN not only achieved effectively bound to the nanocomposite hydrogel, but also released in a controlled and pH-dependent manner. The application of an external magnetic field could significantly enhance the drug release percentage, so that only about % 54.1 GFN was released within 24?h in pH 7.4 for free Fe3O4- nanocomposite, whereas that was % 90.4 for nanocomposite with % 0.83 Fe3O4 at the same condition. More importantly, the released GFN preserved its bioavailability. Taken together, these hydrogel drug carriers provide a promising platform for magnetically targeted drug delivery as well as a dress for wound healing.

» Author: Shabnam Nezami, Mohammad Sadeghi, Hamidreza Mohajerani

» Publication Date: 01/09/2020

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This project has received funding from the Bio-Based Industries Joint Undertaking under the European Union’s Horizon 2020 research and innovation programme under grant agreement Nº 745828